BDBM793727 4-((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamido)-2-((Z)—N''-hydroxycarbamimidoyl)pyridine 1-oxide 43::US20260055088, Example 43

SMILES COc1c([C@H]2[C@H](C(=O)Nc3cc[n+]([O-])c(/C(N)=N/O)c3)O[C@@](C)(C(F)(F)F)[C@H]2C)ccc(F)c1F

InChI Key InChIKey=RFLMOTPVJVYHKP-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 793727   

TargetSodium channel protein type 8 subunit alpha(Human)
Jiangsu Hengrui Pharmaceuticals Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 793727BDBM793727(4-((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 0.300nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2026
Entry Details US Patent