BDBM799262 N-(2-((5-cyano- 4-((2- (isopropylthiophenyl) amino) pyrimidin-2- yl)amino)-5-(4- (4- methylpiperazin- 1-yl)piperidin-1- yl)phenyl) acrylamide::US12582654, Example 81

SMILES C=CC(=O)Nc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(C#N)c(Nc2ccccc2SC(C)C)n1

InChI Key InChIKey=DAZBKRUKXBLCPA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 799262   

TargetFibroblast growth factor receptor 4 [V550L](Human)
Beijing Scitech-MQ Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 799262BDBM799262(N-(2-((5-cyano- 4-((2- (isopropylthiophenyl) amino...)
Affinity DataIC50: 10nMAssay Description:This example demonstrates the ability of the compounds of the disclosure to degrade a Nano luciferase-BRO9 fusion protein in a cell-based degradation...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Beijing Scitech-MQ Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 799262BDBM799262(N-(2-((5-cyano- 4-((2- (isopropylthiophenyl) amino...)
Affinity DataIC50: 10nMAssay Description:This example demonstrates the ability of the compounds of the disclosure to degrade a Nano luciferase-BRO9 fusion protein in a cell-based degradation...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent