BDBM801893 5-fluoro-2-((6-(1-hydroxyethyl)pyridin-3- yl)amino)pyrimidin-4-yl)-1H-indol-7-yl)-3- methoxy-2-(4-methylpiperazin-1-yl)propanamide (isomer 1)::US12606544, Example 29

SMILES COC[C@H](C(=O)Nc1cccc2c(-c3nc(Nc4ccc(C(C)O)nc4)ncc3F)c[nH]c12)N1CCN(C)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 801893   

TargetTyrosine-protein kinase JAK1(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801893BDBM801893(5-fluoro-2-((6-(1-hydroxyethyl)pyridin-3- yl)amino...)
Affinity DataIC50: 0.310nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801893BDBM801893(5-fluoro-2-((6-(1-hydroxyethyl)pyridin-3- yl)amino...)
Affinity DataIC50: 74nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801893BDBM801893(5-fluoro-2-((6-(1-hydroxyethyl)pyridin-3- yl)amino...)
Affinity DataIC50: 939nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801893BDBM801893(5-fluoro-2-((6-(1-hydroxyethyl)pyridin-3- yl)amino...)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent