BDBM801899 (R)-N-(3-(5-fluoro-2-((1-oxo-1,2,3,4- tetrahydroisoquinolin-7-yl)amino)pyrimidin-4-yl)- 1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1- yl)propanamide::US12606544, Example 35

SMILES COC[C@H](C(=O)Nc1cccc2c(-c3nc(Nc4ccc5c(c4)C(=O)NCC5)ncc3F)c[nH]c12)N1CCN(C)CC1

InChI Key InChIKey=NIEWUYXNSAGZLY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 801899   

TargetTyrosine-protein kinase JAK1(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801899BDBM801899((R)-N-(3-(5-fluoro-2-((1-oxo-1,2,3,4- tetrahydrois...)
Affinity DataIC50: 0.260nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801899BDBM801899((R)-N-(3-(5-fluoro-2-((1-oxo-1,2,3,4- tetrahydrois...)
Affinity DataIC50: 199nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801899BDBM801899((R)-N-(3-(5-fluoro-2-((1-oxo-1,2,3,4- tetrahydrois...)
Affinity DataIC50: 2.04E+3nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 801899BDBM801899((R)-N-(3-(5-fluoro-2-((1-oxo-1,2,3,4- tetrahydrois...)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent