BDBM801928 2-(difluoromethoxy)-N- [(1R,2S)-2- fluorocyclopropyl]-4- [6-(2-hydroxy-1,1- dimethyl- ethoxy)pyrazolo[1,5- a]pyridin-3-yl]-6- methoxy-benzamide::US12606554, Compound 2

SMILES COc1cc(-c2cnn3cc(OC(C)(C)CO)ccc23)cc(OC(F)F)c1C(=O)N[C@@H]1C[C@@H]1F

InChI Key InChIKey=YKEJTMGCKFMGKB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 801928   

TargetSerine/threonine-protein kinase SIK3(Human)
Onco3R Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 801928BDBM801928(2-(difluoromethoxy)-N- [(1R,2S)-2- fluorocycloprop...)
Affinity DataIC50: 5.00nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Onco3R Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 801928BDBM801928(2-(difluoromethoxy)-N- [(1R,2S)-2- fluorocycloprop...)
Affinity DataIC50: 300nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Onco3R Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 801928BDBM801928(2-(difluoromethoxy)-N- [(1R,2S)-2- fluorocycloprop...)
Affinity DataIC50: 500nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent