BDBM801930 8-methoxy-6-[6-(2- morpholinoethoxy) pyrazolo[1,5-a]pyrimidin-3- yl]-2-(2,2,2- trifluoroethyl)-3,4- dihydroisoquinolin-1- one::US12606554, Compound 4

SMILES COc1cc(-c2cnn3cc(OCCN4CCOCC4)cnc23)cc2c1C(=O)N(CC(F)(F)F)CC2

InChI Key InChIKey=YAUOGWZWDYXEJH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 801930   

TargetSerine/threonine-protein kinase SIK2(Human)
Onco3R Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 801930BDBM801930(8-methoxy-6-[6-(2- morpholinoethoxy) pyrazolo[1,5-...)
Affinity DataIC50: 55nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Onco3R Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 801930BDBM801930(8-methoxy-6-[6-(2- morpholinoethoxy) pyrazolo[1,5-...)
Affinity DataIC50: 55nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Onco3R Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 801930BDBM801930(8-methoxy-6-[6-(2- morpholinoethoxy) pyrazolo[1,5-...)
Affinity DataIC50: 500nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent