BDBM802067 US20260108613, Compound A12::methyl (S)-3-((2S,4R)-1-((S)- 5-acetyl-3-cyclopropyl-7,7- dimethyl-5,6,7,8-tetrahydro- 4H-[1,2,3]triazolo[1,5-a][1,4] diazepine-8-carbonyl)-4- hydroxypyrrolidine-2-carbox- amido)-3-(4-(4-methylthiazol- 5-yl)phenyl)propanoate

SMILES COC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H]4n3nnc(C2CC2)c3CN(C(C)=O)CC4(C)C)c6ccc(c5scnc5C)cc6

InChI Key InChIKey=GWMRGYMJXFJBLO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 802067   

Targetvon Hippel-Lindau disease tumor suppressor(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 802067BDBM802067(methyl (S)-3-((2S,4R)-1-((S)- 5-acetyl-3-cycloprop...)
Affinity DataIC50: 2.30nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent