BDBM802723 N5-((5,6-dihydro-8H- [1,2,4]triazolo[3,4- c][1,4]oxazin-3-yl)methyl)- N5,1-dimethyl-1H- benzo[d]imidazole-2,5- diamine::US20260109709, Example 1-83

SMILES CN(Cc1nnc2n1CCOC2)c1ccc2c(c1)nc(N)n2C

InChI Key InChIKey=SWJCYYRHSRGMBL-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 802723   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 802723BDBM802723(N5-((5,6-dihydro-8H- [1,2,4]triazolo[3,4- c][1,4]o...)
Affinity DataKd:  89nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 802723BDBM802723(N5-((5,6-dihydro-8H- [1,2,4]triazolo[3,4- c][1,4]o...)
Affinity DataIC50: 1.37E+4nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 802723BDBM802723(N5-((5,6-dihydro-8H- [1,2,4]triazolo[3,4- c][1,4]o...)
Affinity DataIC50: 1.37E+4nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 802723BDBM802723(N5-((5,6-dihydro-8H- [1,2,4]triazolo[3,4- c][1,4]o...)
Affinity DataIC50: 3.00E+5nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent