BDBM802759 2-amino-6-[ (2- cyanophenyl)methyl]-3-methyl- benzimidazole-4-carbonitrile. LC-MS [M + 1] + = 288.2. 1H NMR (400 MHz, MeOH-d4) $#948; = 7.73 (dd, J = 1.1, 7.6 Hz, 1H), 7.69 - 7.62 (m, 1H), 7.57 - 7.49 (m, 3H), 7.45 (dt, J = 1.2, 7.6 Hz, 1H), 4.34 (s, 2H), 3.92 (s, 3H).::US20260109709, Example 3-10

SMILES Cn1c(N)nc2cc(Cc3ccccc3C#N)cc(C#N)c21

InChI Key InChIKey=REVFVVANIHEDRG-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 802759   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 802759BDBM802759(2-amino-6-[ (2- cyanophenyl)methyl]-3-methyl- benz...)
Affinity DataKd:  8nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 802759BDBM802759(2-amino-6-[ (2- cyanophenyl)methyl]-3-methyl- benz...)
Affinity DataIC50: 17nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 802759BDBM802759(2-amino-6-[ (2- cyanophenyl)methyl]-3-methyl- benz...)
Affinity DataIC50: 69nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 802759BDBM802759(2-amino-6-[ (2- cyanophenyl)methyl]-3-methyl- benz...)
Affinity DataIC50: 1.00E+4nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent