BDBM803587 5-chloro-4-((3aR,6aS)-3a,6a-dimethyl-5-(pyrimidin-4-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine::US20260116887, Compound 25.

SMILES Cn1cc(Nc2ncc(Cl)c(N3C[C@]4(C)CN(c5ccncn5)C[C@]4(C)C3)n2)cn1

InChI Key InChIKey=KJSNWXIVOXLRJO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 803587   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Guangzhou Innocare Pharma Tech Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803587BDBM803587(5-chloro-4-((3aR,6aS)-3a,6a-dimethyl-5-(pyrimidin-...)
Affinity DataIC50: 0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Guangzhou Innocare Pharma Tech Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803587BDBM803587(5-chloro-4-((3aR,6aS)-3a,6a-dimethyl-5-(pyrimidin-...)
Affinity DataIC50: 0.900nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2026
Entry Details
US Patent