BDBM803591 ((3aR,6aS)-5-(2-((1H-pyrazol-4-yl)amino)-5-chloropyrimidin-4-yl)-3a,6a-dimethylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)((S)-2,2-difluorocyclopropyl)methanone::US20260116887, Compound 29.

SMILES C[C@@]12CN(C(=O)[C@@H]3CC3(F)F)C[C@]1(C)CN(c1nc(Nc3cn[nH]c3)ncc1Cl)C2

InChI Key InChIKey=YRDXJSUJDAHHTE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 803591   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Guangzhou Innocare Pharma Tech Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803591BDBM803591(((3aR,6aS)-5-(2-((1H-pyrazol-4-yl)amino)-5-chlorop...)
Affinity DataIC50: 0.400nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Guangzhou Innocare Pharma Tech Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803591BDBM803591(((3aR,6aS)-5-(2-((1H-pyrazol-4-yl)amino)-5-chlorop...)
Affinity DataIC50: 0.5nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2026
Entry Details
US Patent