BDBM803603 5-chloro-4-((3aR,6aS)-5-(ethylsulfonyl)-3a,6a-dimethylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine::US20260116887, Compound 41.

SMILES CCS(=O)(=O)N1C[C@]2(C)CN(c3nc(Nc4cnn(C)c4)ncc3Cl)C[C@]2(C)C1

InChI Key InChIKey=VPTZPCNSVWUCKR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 803603   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Guangzhou Innocare Pharma Tech Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803603BDBM803603(5-chloro-4-((3aR,6aS)-5-(ethylsulfonyl)-3a,6a-dime...)
Affinity DataIC50: 1.30nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Guangzhou Innocare Pharma Tech Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803603BDBM803603(5-chloro-4-((3aR,6aS)-5-(ethylsulfonyl)-3a,6a-dime...)
Affinity DataIC50: 1.70nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2026
Entry Details
US Patent