BDBM803660 3-((3aS,6aR)-5-(2-((1H-pyrazol-4-yl)amino)-5-chloropyrimidin-4-yl)-3a-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-oxopropanenitrile::US20260116887, Compound 98.

SMILES C[C@]12CN(C(=O)CC#N)C[C@H]1CN(c1nc(Nc3cn[nH]c3)ncc1Cl)C2

InChI Key InChIKey=JKQTWCGZSNVOHP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 803660   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Guangzhou Innocare Pharma Tech Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803660BDBM803660(3-((3aS,6aR)-5-(2-((1H-pyrazol-4-yl)amino)-5-chlor...)
Affinity DataIC50: 0.100nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Guangzhou Innocare Pharma Tech Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803660BDBM803660(3-((3aS,6aR)-5-(2-((1H-pyrazol-4-yl)amino)-5-chlor...)
Affinity DataIC50: 0.700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2026
Entry Details
US Patent