BDBM803661 3-((3aS,6aR)-5-(5-chloro-2-((1-(methyl-d3)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3a-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-oxopropanenitrile::US20260116887, Compound 99.

SMILES [2H]C([2H])([2H])n1cc(Nc2ncc(Cl)c(N3C[C@@H]4CN(C(=O)CC#N)C[C@]4(C)C3)n2)cn1

InChI Key InChIKey=OWDNRVGFIXZHAC-BMSJAHLVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 803661   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Guangzhou Innocare Pharma Tech Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803661BDBM803661(3-((3aS,6aR)-5-(5-chloro-2-((1-(methyl-d3)-1H-pyra...)
Affinity DataIC50: 0.100nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Guangzhou Innocare Pharma Tech Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803661BDBM803661(3-((3aS,6aR)-5-(5-chloro-2-((1-(methyl-d3)-1H-pyra...)
Affinity DataIC50: 0.5nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2026
Entry Details
US Patent