BDBM803749 4-((S)-4-((S)-2-(4-chlorophenyl)-3-(isopropylamino)propionyl)-3-methylpiperazin-1-yl)-5-methyl-5,8-dihydropteridine-7(6H)-one::US12617784, Example 22

SMILES CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2N(C)CC(=O)N3)C[C@@H]1C)c1ccc(Cl)cc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 803749   

TargetRAC-gamma serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803749BDBM803749(4-((S)-4-((S)-2-(4-chlorophenyl)-3-(isopropylamino...)
Affinity DataIC50: 0.560nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803749BDBM803749(4-((S)-4-((S)-2-(4-chlorophenyl)-3-(isopropylamino...)
Affinity DataIC50: 39nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetRAC-beta serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803749BDBM803749(4-((S)-4-((S)-2-(4-chlorophenyl)-3-(isopropylamino...)
Affinity DataIC50: 334nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent