BDBM803761 US12617784, Example 29

SMILES CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2N(CC#N)CC(=O)N3)CC1)c1ccc(Cl)cc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 803761   

TargetRAC-gamma serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803761BDBM803761(US12617784, Example 29)
Affinity DataIC50: 1.10nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803761BDBM803761(US12617784, Example 29)
Affinity DataIC50: 40nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent

TargetRAC-beta serine/threonine-protein kinase(Human)
Nanjing Chia Tai Tianqing Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 803761BDBM803761(US12617784, Example 29)
Affinity DataIC50: 227nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/14/2026
Entry Details
US Patent