BDBM805019 US20260125375, Example C11

SMILES C[C@@H](NC1CCCC1)c1nc(C(F)(F)F)cc2c(-c3cccc([C@H](c4nncn4C)C4CCC4)c3)n[nH]c12

InChI Key InChIKey=GYSCUXXZLBWAJE-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 805019   

TargetE3 ubiquitin-protein ligase CBL-B [36-427](Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 805019BDBM805019(US20260125375, Example C11)
Affinity DataKi:  0.600nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/17/2026
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C [46-435](Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 805019BDBM805019(US20260125375, Example C11)
Affinity DataKi:  3.70nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/17/2026
Entry Details
US Patent