BDBM805551 ((4S)-1,1-Difluoro-4-(hydroxymethyl)-5-azaspiro[2.3]hexan-5-yl)(6-(5-fluoro-2-(((3S,4R)-3-hydroxytetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-methyl-1H-indol-3-yl)methanone and ((4R)-1,1-Difluoro-4-(hydroxymethyl)-5-azaspiro[2.3]hexan-5-yl)(6-(5-fluoro-2-(((3S,4R)-3-hydroxytetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-methyl-1H-indol-3-yl)methanone::US20260125391, Example 63

SMILES Cn1cc(C(=O)N2CC3(CC3(F)F)[C@@H]2CO)c2ccc(-c3nc(N[C@@H]4CCOC[C@H]4O)ncc3F)cc21

InChI Key InChIKey=ZQKXCOWBOPGNIZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 805551   

LigandChemical structure of BindingDB Monomer ID 805551BDBM805551(((4S)-1,1-Difluoro-4-(hydroxymethyl)-5-azaspiro[2....)
Affinity DataIC50: 10nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/17/2026
Entry Details
US Patent