BDBM805581 (1-Ethyl-6-(5-fluoro-2- (((3S,4R)-3- hydroxytetrahydro-2H- pyran-4- yl)amino)pyrimidin-4- yl)-1H-indol-3-yl)((S)- 2-(hydroxymethyl)-4,4- dimethylpyrrolidin-1- yl)methanone::US20260125391, Example 93

SMILES CCn1cc(C(=O)N2CC(C)(C)C[C@H]2CO)c2ccc(-c3nc(N[C@@H]4CCOC[C@H]4O)ncc3F)cc21

InChI Key InChIKey=PCLFRJFIOZWMBF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 805581   

LigandChemical structure of BindingDB Monomer ID 805581BDBM805581((1-Ethyl-6-(5-fluoro-2- (((3S,4R)-3- hydroxytetrah...)
Affinity DataIC50: 10nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/17/2026
Entry Details
US Patent