BDBM805891 N-(1-(tert-butyl)-1H-pyrazol-4-yl)-2-(3-methyl-4-((6-(methylsulfonyl)quinolin-4-yl)oxy)phenyl)acetamide ::US12624018, Compound 86

SMILES Cc1cc(CC(=O)Nc2cnn(C(C)(C)C)c2)ccc1Oc1ccnc2ccc(S(C)(=O)=O)cc12

InChI Key InChIKey=RKQQHOVTDFFSCU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 805891   

LigandChemical structure of BindingDB Monomer ID 805891BDBM805891(N-(1-(tert-butyl)-1H-pyrazol-4-yl)-2-(3-methyl-4-(...)
Affinity DataIC50: 0.700nMAssay Description:Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2026
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Odyssey Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 805891BDBM805891(N-(1-(tert-butyl)-1H-pyrazol-4-yl)-2-(3-methyl-4-(...)
Affinity DataIC50: 2.5nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/21/2026
Entry Details
US Patent