BDBM806246 US12624018, Compound 441

SMILES Cc1c(Oc2ccnc3ccc([S@](=N)(=O)C4CC4)cc23)ccc(CC(=O)Nc2cnn(C(C)(C)C)c2)c1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 806246   

LigandChemical structure of BindingDB Monomer ID 806246BDBM806246(US12624018, Compound 441)
Affinity DataIC50: 0.200nMAssay Description:Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2026
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Odyssey Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 806246BDBM806246(US12624018, Compound 441)
Affinity DataIC50: 2.5nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2026
Entry Details
US Patent