BDBM806294 4-(4-(2-((1-(tert-butyl)-1H-pyrazol-4-yl)amino)-2-oxoethyl)-2-methylphenoxy)-7-fluoro-N-methylquinoline-6-carboxamide ::US12624018, Compound 490

SMILES CNC(=O)c1cc2c(Oc3ccc(CC(=O)Nc4cnn(C(C)(C)C)c4)cc3C)ccnc2cc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 806294   

LigandChemical structure of BindingDB Monomer ID 806294BDBM806294(4-(4-(2-((1-(tert-butyl)-1H-pyrazol-4-yl)amino)-2-...)
Affinity DataIC50: 0.100nMAssay Description:Biochemical JAK and Off-Target Kinase Assays. A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kin...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2026
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Odyssey Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 806294BDBM806294(4-(4-(2-((1-(tert-butyl)-1H-pyrazol-4-yl)amino)-2-...)
Affinity DataIC50: 2.5nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2026
Entry Details
US Patent