BDBM806295 US12624018, Compound 491

SMILES [2H]C([2H])([2H])NC(=O)c1ccc2nccc(Oc3ccc(CC(=O)Nc4cnn(C(C)(C)C)c4)cc3C)c2c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 806295   

LigandChemical structure of BindingDB Monomer ID 806295BDBM806295(US12624018, Compound 491)
Affinity DataIC50: 0.100nMAssay Description:Biochemical JAK and Off-Target Kinase Assays. A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kin...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2026
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Odyssey Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 806295BDBM806295(US12624018, Compound 491)
Affinity DataIC50: 2.5nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/21/2026
Entry Details
US Patent