BDBM806872 (7R)-2-[(1S*,5R*)-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-(2-fluorophenyl)sulfonyl]-2-azaspiro[3.3]heptan-6-yl]-7-methyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one::US20260132127, Example 168

SMILES C[C@@H]1COc2nc(N3C[C@H]4C[C@H]4C3)ncc2C(=O)N1C1CC2(C1)CN(S(=O)(=O)c1ccccc1F)C2

InChI Key InChIKey=FCFFNHMEJZMAEP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 806872   

TargetThyrotropin-releasing hormone-degrading ectoenzyme(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 806872BDBM806872((7R)-2-[(1S*,5R*)-3-azabicyclo[3.1.0]hexan-3-yl]-6...)
Affinity DataIC50: 2nMAssay Description:Biochemical JAK and Off-Target Kinase Assays. A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent