BDBM806949 (3R)-4-[2-(2-fluorophenyl)sulfonyl-2-azaspiro[3.3]heptan-6-yl]-1,3-dimethyl-8-(trifluoromethyl)-2,3-dihydropyrido[2,3-e][1,4]diazepin-5-one::US20260132127, Example 247

SMILES C[C@@H]1CN(C)c2nc(C(F)(F)F)ccc2C(=O)N1C1CC2(C1)CN(S(=O)(=O)c1ccccc1[N+](=O)[O-])C2

InChI Key InChIKey=JKBODXBOQQCAMV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 806949   

TargetThyrotropin-releasing hormone-degrading ectoenzyme(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 806949BDBM806949((3R)-4-[2-(2-fluorophenyl)sulfonyl-2-azaspiro[3.3]...)
Affinity DataIC50: 2nMAssay Description:Biochemical JAK and Off-Target Kinase Assays. A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent