BDBM806953 (3R)-8-chloro-4-[2-(2-fluorophenyl)sulfonyl-2-azaspiro[3.3]heptan-6-yl]-3-methyl-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepin-5-one::US20260132127, Example 251

SMILES C[C@@H]1CNc2nc(Cl)ccc2C(=O)N1C1CC2(C1)CN(S(=O)(=O)c1ccccc1F)C2

InChI Key InChIKey=AIJZAJTVVOZANT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 806953   

TargetThyrotropin-releasing hormone-degrading ectoenzyme(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 806953BDBM806953((3R)-8-chloro-4-[2-(2-fluorophenyl)sulfonyl-2-azas...)
Affinity DataIC50: 1nMAssay Description:Biochemical JAK and Off-Target Kinase Assays. A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent