BDBM807254 1-(3-chlorophenyl)-N-(cyclopropylmethyl)-6-(2'-ethyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide::US20260132132, Example 1099

SMILES CCN1Cc2cc(N3CCc4c(C(=O)NCC5CC5)nn(-c5cccc(Cl)c5)c4C3=O)ccc2C2(CC2)C1

InChI Key InChIKey=CNFHOOLFKZOEIR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 807254   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 807254BDBM807254(1-(3-chlorophenyl)-N-(cyclopropylmethyl)-6-(2'-eth...)
Affinity DataIC50: 55nMAssay Description:Biochemical JAK and Off-Target Kinase Assays. A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetCoagulation factor X(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 807254BDBM807254(1-(3-chlorophenyl)-N-(cyclopropylmethyl)-6-(2'-eth...)
Affinity DataIC50: 6.50E+3nMAssay Description:Recombinant KRAS G12C (amino acids 1-169, SEQ ID NO:1), KRAS G12D (amino acids 1-169, SEQ ID NO:2), KRAS G12V (amino acids 1-169, SEQ ID NO:3) and SO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent