BDBM807605 1-(3-(aminomethyl)-5-chlorophenyl)-N-(cyclopropylmethyl)-6-(2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide::US20260132132, Example 2018

SMILES CN1CCc2ccc(N3CCc4c(C(=O)NCC5CC5)nn(-c5cc(Cl)cc(CN)c5)c4C3=O)cc2C1=O

InChI Key InChIKey=JFUGPKGQIGUFIN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 807605   

TargetSerine protease 1(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 807605BDBM807605(1-(3-(aminomethyl)-5-chlorophenyl)-N-(cyclopropylm...)
Affinity DataIC50: 5.5nMAssay Description:Table 8: In vitro inhibition of related proteases was determined using a single-concentration % inhibition screen and/or IC50 determination at releva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 807605BDBM807605(1-(3-(aminomethyl)-5-chlorophenyl)-N-(cyclopropylm...)
Affinity DataIC50: 55nMAssay Description:Recombinant KRAS G12C (amino acids 1-169, SEQ ID NO:1), KRAS G12D (amino acids 1-169, SEQ ID NO:2), KRAS G12V (amino acids 1-169, SEQ ID NO:3) and SO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetPlasminogen(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 807605BDBM807605(1-(3-(aminomethyl)-5-chlorophenyl)-N-(cyclopropylm...)
Affinity DataIC50: 650nMAssay Description:Table 8: In vitro inhibition of related proteases was determined using a single-concentration % inhibition screen and/or IC50 determination at releva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetProthrombin(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 807605BDBM807605(1-(3-(aminomethyl)-5-chlorophenyl)-N-(cyclopropylm...)
Affinity DataIC50: 2.50E+4nMAssay Description:Table 8: In vitro inhibition of related proteases was determined using a single-concentration % inhibition screen and/or IC50 determination at releva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 807605BDBM807605(1-(3-(aminomethyl)-5-chlorophenyl)-N-(cyclopropylm...)
Affinity DataIC50: 4.00E+4nMAssay Description:Table 8: In vitro inhibition of related proteases was determined using a single-concentration % inhibition screen and/or IC50 determination at releva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 807605BDBM807605(1-(3-(aminomethyl)-5-chlorophenyl)-N-(cyclopropylm...)
Affinity DataIC50: 4.00E+4nMAssay Description:Table 8: In vitro inhibition of related proteases was determined using a single-concentration % inhibition screen and/or IC50 determination at releva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetCoagulation factor X(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 807605BDBM807605(1-(3-(aminomethyl)-5-chlorophenyl)-N-(cyclopropylm...)
Affinity DataIC50: 4.00E+4nMAssay Description:Table 8: In vitro inhibition of related proteases was determined using a single-concentration % inhibition screen and/or IC50 determination at releva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 807605BDBM807605(1-(3-(aminomethyl)-5-chlorophenyl)-N-(cyclopropylm...)
Affinity DataIC50: 4.00E+4nMAssay Description:Table 8: In vitro inhibition of related proteases was determined using a single-concentration % inhibition screen and/or IC50 determination at releva...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent