BDBM807689 3-(5-Hydroxypyrazin-2-yl)-2-((4-(trifluoromethyl)benzyl)thio)-5-vinylpyrazolo[5,1-f][1,2,4]triazin-4(3H)-one::US20260132136, Example 19
SMILES C=Cc1cnn2nc(SCc3ccc(C(F)(F)F)cc3)n(C3=NCC(O)N=C3)c(=O)c12
InChI Key InChIKey=MGMCOAWQDIJDKB-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 807689
Affinity DataIC50: 60nMAssay Description:NOX4 inhibition is assessed utilizing HEK293 cells stably overexpressing human NOX4 (hNOX4), generating constitutively high levels of hydrogen peroxi...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Evaluation of the NOX4 inhibitors on NOX5 activity is assessed in HEK293 cells stably overexpressing human NOX5 (hNOX5).Cells are cultured in the DME...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+4nMAssay Description:Evaluation of the NOX4 inhibitors on NOX1 activity is assessed in HEK293 cells stably overexpressing human NOX1 (hNOX1).Cells are cultured in the DME...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40E+4nMAssay Description:Evaluation of the NOX4 inhibitors on NOX3 activity is assessed in HEK293 cells stably overexpressing human NOX3 (hNOX3).Cells are cultured in the DME...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Evaluation of the NOX4 inhibitors on NOX2 activity is assessed in human blood-derived granulocytes.Different concentrations of the test compounds (30...More data for this Ligand-Target Pair