BDBM807692 5-(2,2-Difluorovinyl)-3-(5-hydroxypyrazin-2-yl)-2-((4-(trifluoromethyl)benzyl)thio)pyrazolo[5,1-f][1,2,4]triazin-4(3H)-one::US20260132136, Example 22

SMILES O=c1c2c(C=C(F)F)cnn2nc(SCc2ccc(C(F)(F)F)cc2)n1-c1cnc(O)cn1

InChI Key InChIKey=GCZXQAIQFJSJNC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 807692   

TargetNADPH oxidase 4(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 807692BDBM807692(5-(2,2-Difluorovinyl)-3-(5-hydroxypyrazin-2-yl)-2-...)
Affinity DataIC50: 350nMAssay Description:NOX4 inhibition is assessed utilizing HEK293 cells stably overexpressing human NOX4 (hNOX4), generating constitutively high levels of hydrogen peroxi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetNADPH oxidase 1(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 807692BDBM807692(5-(2,2-Difluorovinyl)-3-(5-hydroxypyrazin-2-yl)-2-...)
Affinity DataIC50: 3.50E+3nMAssay Description:Evaluation of the NOX4 inhibitors on NOX1 activity is assessed in HEK293 cells stably overexpressing human NOX1 (hNOX1).Cells are cultured in the DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetNADPH oxidase 5(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 807692BDBM807692(5-(2,2-Difluorovinyl)-3-(5-hydroxypyrazin-2-yl)-2-...)
Affinity DataIC50: 1.40E+4nMAssay Description:Evaluation of the NOX4 inhibitors on NOX5 activity is assessed in HEK293 cells stably overexpressing human NOX5 (hNOX5).Cells are cultured in the DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetNADPH oxidase 3(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 807692BDBM807692(5-(2,2-Difluorovinyl)-3-(5-hydroxypyrazin-2-yl)-2-...)
Affinity DataIC50: 2.20E+4nMAssay Description:Evaluation of the NOX4 inhibitors on NOX3 activity is assessed in HEK293 cells stably overexpressing human NOX3 (hNOX3).Cells are cultured in the DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetCytochrome b-245 heavy chain(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 807692BDBM807692(5-(2,2-Difluorovinyl)-3-(5-hydroxypyrazin-2-yl)-2-...)
Affinity DataIC50: 2.51E+4nMAssay Description:Evaluation of the NOX4 inhibitors on NOX2 activity is assessed in human blood-derived granulocytes.Different concentrations of the test compounds (30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent