BDBM807695 5-Fluoro-3-(6-fluoro-5-hydroxypyrazin-2-yl)-2-((4-(trifluoromethyl)benzyl)thio)pyrazolo[5,1-f][1,2,4]triazin-4(3H)-one::US20260132136, Example 25
SMILES O=c1c2c(F)cnn2nc(SCc2ccc(C(F)(F)F)cc2)n1-c1cnc(O)c(F)n1
InChI Key InChIKey=SZOAQLKIPOJSJZ-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 807695
Affinity DataIC50: 73nMAssay Description:NOX4 inhibition is assessed utilizing HEK293 cells stably overexpressing human NOX4 (hNOX4), generating constitutively high levels of hydrogen peroxi...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Evaluation of the NOX4 inhibitors on NOX1 activity is assessed in HEK293 cells stably overexpressing human NOX1 (hNOX1).Cells are cultured in the DME...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Evaluation of the NOX4 inhibitors on NOX5 activity is assessed in HEK293 cells stably overexpressing human NOX5 (hNOX5).Cells are cultured in the DME...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:Evaluation of the NOX4 inhibitors on NOX3 activity is assessed in HEK293 cells stably overexpressing human NOX3 (hNOX3).Cells are cultured in the DME...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Evaluation of the NOX4 inhibitors on NOX2 activity is assessed in human blood-derived granulocytes.Different concentrations of the test compounds (30...More data for this Ligand-Target Pair