BDBM808257 Preparation of 1-methyl-N-(7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-amine (Ex. 2) and 3-(3,6-dihydro-2H-pyran-4-yl)-1-methyl-N-[7-methylimidazo[1,2-a]pyridin-6-yl]pyrazolo[4,3-d]pyrimidin-5-amine. (Ex. 6)::US12630565, Example 2

SMILES Cc1cc2nccn2cc1Nc1ncc2c(n1)c(C1CCOCC1)nn2C

InChI Key InChIKey=CZAAQKBGXNQQKD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 808257   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808257BDBM808257(Preparation of 1-methyl-N-(7-methyl-[1,2,4]triazol...)
Affinity DataIC50: 1.40nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand Info
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Date in BDB:
12/4/2017
Entry Details
US Patent