BDBM808278 Preparation of 3-((1r,4r)-4-methoxycyclohexyl)-1-methyl-N-(7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-amine (Ex. 7) and 3-((1s,4s)-4-methoxycyclohexyl)-1-methyl-N-(7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-amine (Ex. 8)::US12630565, Example 8

SMILES CO[C@H]1CC[C@@H](c2nn(C)c3cnc(Nc4cn5ncnc5cc4C)nc32)CC1

InChI Key InChIKey=WLXNSRMBDUBMMC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 808278   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808278BDBM808278(Preparation of 3-((1r,4r)-4-methoxycyclohexyl)-1-m...)
Affinity DataIC50: 0.700nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent