BDBM808282 Preparation of 1-(methyl-d3)—N-(7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-amine (Ex. 10)::US12630565, Example 10

SMILES [2H]C([2H])([2H])n1nc(C2CCOCC2)c2nc(Nc3cn4ncnc4cc3C)ncc21

InChI Key InChIKey=PLLDARXQNHJJGG-BMSJAHLVSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 808282   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808282BDBM808282(Preparation of 1-(methyl-d3)—N-(7-methyl-[1,2,4]tr...)
Affinity DataIC50: 1.70nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent