BDBM808317 Preparation of 3-(3-methyl-6-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propanenitrile (Ex. 72)::US12630565, Example 72

SMILES Cc1cc2ncnn2cc1Nc1ncc2c(C)nn(CCC#N)c2n1

InChI Key InChIKey=MIOBSGVEZLRHSD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 808317   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808317BDBM808317(Preparation of 3-(3-methyl-6-((7-methyl-[1,2,4]tri...)
Affinity DataIC50: 1.80nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent