BDBM808353 1-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-3- methyl-N-(7-methyl-[1,2,4]triazolo[1,5- a]pyridin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-6- amine (isomer 2)::US12630565, Example 117

SMILES Cc1cc2ncnn2cc1Nc1ncc2c(C)nn(C3CCOC(C)(C)C3)c2n1

InChI Key InChIKey=NFXNGNNDARFTNP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 808353   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Dizal (Jiangsu) Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808353BDBM808353(1-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-3- methyl...)
Affinity DataIC50: 1.80nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent