BDBM808478 2-(2,3- dihydrobenzofuran-5- yl)-N-(4-(6-methoxy- 7-(3-(4- methylpiperazin-1- yl)propoxy) quinazolin-4- yl)phenyl)acetamide::US20260138959, Example 85

SMILES COc1cc2c(-c3ccc(NC(=O)Cc4ccc5c(c4)CCO5)cc3)ncnc2cc1OCCCN1CCN(C)CC1

InChI Key InChIKey=QHQLFRJWGLTWIR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 808478   

TargetPlatelet-derived growth factor receptor alpha(Human)
Voronoi

US Patent
LigandChemical structure of BindingDB Monomer ID 808478BDBM808478(2-(2,3- dihydrobenzofuran-5- yl)-N-(4-(6-methoxy- ...)
Affinity DataIC50: 50nMAssay Description:In order to evaluate the inhibitory activity of the compounds synthesized according to the above examples on PDGFR-α(wt), PDGFR-β(wt), c-KIT(wt), and...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Voronoi

US Patent
LigandChemical structure of BindingDB Monomer ID 808478BDBM808478(2-(2,3- dihydrobenzofuran-5- yl)-N-(4-(6-methoxy- ...)
Affinity DataIC50: 50nMAssay Description:In order to evaluate the inhibitory activity of the compounds synthesized according to the above examples on PDGFR-α(wt), PDGFR-β(wt), c-KIT(wt), and...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent