BDBM808503 N-(4-(6-(3-(6- ethyl-2,6-diaza- spiro[3.3]heptane- 2-yl)propoxy)-7- methoxyquinaz- olin-4-yl)phenyl)- 2-(4-trifluorometh- yl)phenyl)acet- amide::US20260138959, Example 149

SMILES CCN1CC2(C1)CN(CCCOc1cc3c(-c4ccc(NC(=O)Cc5ccc(C(F)(F)F)cc5)cc4)ncnc3cc1OC)C2

InChI Key InChIKey=ZLQRFLWSSYPYQG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 808503   

TargetPlatelet-derived growth factor receptor alpha(Human)
Voronoi

US Patent
LigandChemical structure of BindingDB Monomer ID 808503BDBM808503(N-(4-(6-(3-(6- ethyl-2,6-diaza- spiro[3.3]heptane-...)
Affinity DataIC50: 50nMAssay Description:In order to evaluate the inhibitory activity of the compounds synthesized according to the above examples on PDGFR-α(wt), PDGFR-β(wt), c-KIT(wt), and...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Voronoi

US Patent
LigandChemical structure of BindingDB Monomer ID 808503BDBM808503(N-(4-(6-(3-(6- ethyl-2,6-diaza- spiro[3.3]heptane-...)
Affinity DataIC50: 50nMAssay Description:In order to evaluate the inhibitory activity of the compounds synthesized according to the above examples on PDGFR-α(wt), PDGFR-β(wt), c-KIT(wt), and...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent