BDBM808576 7-(2-fluoro-6-methyl-phenyl)-N5- [(3R)-pyrrolidin-3-yl]isoquinoline-3,5- diamine::US12637428, Example E4

SMILES Cc1cccc(F)c1-c1cc(N[C@@H]2CCNC2)c2cc(N)ncc2c1

InChI Key InChIKey=LLGZGYWIEGIHBZ-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 808576   

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808576BDBM808576(7-(2-fluoro-6-methyl-phenyl)-N5- [(3R)-pyrrolidin-...)
Affinity DataKi:  0.0700nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808576BDBM808576(7-(2-fluoro-6-methyl-phenyl)-N5- [(3R)-pyrrolidin-...)
Affinity DataKi:  0.231nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808576BDBM808576(7-(2-fluoro-6-methyl-phenyl)-N5- [(3R)-pyrrolidin-...)
Affinity DataKi:  0.354nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808576BDBM808576(7-(2-fluoro-6-methyl-phenyl)-N5- [(3R)-pyrrolidin-...)
Affinity DataKi:  7.79nMAssay Description:Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808576BDBM808576(7-(2-fluoro-6-methyl-phenyl)-N5- [(3R)-pyrrolidin-...)
Affinity DataKi:  138nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEphrin type-A receptor 2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808576BDBM808576(7-(2-fluoro-6-methyl-phenyl)-N5- [(3R)-pyrrolidin-...)
Affinity DataKi:  644nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent