BDBM808583 N5-(azetidin-3-ylmethyl)-7-(2-fluoro- 6-methyl-phenyl)isoquinoline-3,5- diamine::US12637428, Example E11

SMILES Cc1cccc(F)c1-c1cc(NCC2CNC2)c2cc(N)ncc2c1

InChI Key InChIKey=BOMHVYFLJZCKIM-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 808583   

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808583BDBM808583(N5-(azetidin-3-ylmethyl)-7-(2-fluoro- 6-methyl-phe...)
Affinity DataKi:  0.0670nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808583BDBM808583(N5-(azetidin-3-ylmethyl)-7-(2-fluoro- 6-methyl-phe...)
Affinity DataKi:  0.195nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808583BDBM808583(N5-(azetidin-3-ylmethyl)-7-(2-fluoro- 6-methyl-phe...)
Affinity DataKi:  0.417nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808583BDBM808583(N5-(azetidin-3-ylmethyl)-7-(2-fluoro- 6-methyl-phe...)
Affinity DataKi:  0.921nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808583BDBM808583(N5-(azetidin-3-ylmethyl)-7-(2-fluoro- 6-methyl-phe...)
Affinity DataKi:  23.5nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEphrin type-A receptor 2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808583BDBM808583(N5-(azetidin-3-ylmethyl)-7-(2-fluoro- 6-methyl-phe...)
Affinity DataKi:  95.1nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent