BDBM808595 N5-[(3S)-azepan-3-yl]-7-(2-fluoro-6- methyl-phenyl)isoquinoline-3,5- diamine::US12637428, Example E23

SMILES Cc1cccc(F)c1-c1cc(N[C@H]2CCCCNC2)c2cc(N)ncc2c1

InChI Key InChIKey=QMHKWCHNTZQYLJ-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 808595   

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808595BDBM808595(N5-[(3S)-azepan-3-yl]-7-(2-fluoro-6- methyl-phenyl...)
Affinity DataKi:  0.0490nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808595BDBM808595(N5-[(3S)-azepan-3-yl]-7-(2-fluoro-6- methyl-phenyl...)
Affinity DataKi:  0.171nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808595BDBM808595(N5-[(3S)-azepan-3-yl]-7-(2-fluoro-6- methyl-phenyl...)
Affinity DataKi:  0.287nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808595BDBM808595(N5-[(3S)-azepan-3-yl]-7-(2-fluoro-6- methyl-phenyl...)
Affinity DataKi:  3.75nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808595BDBM808595(N5-[(3S)-azepan-3-yl]-7-(2-fluoro-6- methyl-phenyl...)
Affinity DataKi:  15.9nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEphrin type-A receptor 2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808595BDBM808595(N5-[(3S)-azepan-3-yl]-7-(2-fluoro-6- methyl-phenyl...)
Affinity DataKi:  24.6nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent