BDBM808598 7-(2-fluoro-6-methyl-phenyl)-N5- [(3S)-3-piperidyl]isoquinoline-3,5- diamine::US12637428, Example E26

SMILES Cc1cccc(F)c1-c1cc(N[C@H]2CCCNC2)c2cc(N)ncc2c1

InChI Key InChIKey=MBWUDZLBKIOCLW-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 808598   

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808598BDBM808598(7-(2-fluoro-6-methyl-phenyl)-N5- [(3S)-3-piperidyl...)
Affinity DataKi:  0.0400nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808598BDBM808598(7-(2-fluoro-6-methyl-phenyl)-N5- [(3S)-3-piperidyl...)
Affinity DataKi:  0.0840nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808598BDBM808598(7-(2-fluoro-6-methyl-phenyl)-N5- [(3S)-3-piperidyl...)
Affinity DataKi:  0.302nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808598BDBM808598(7-(2-fluoro-6-methyl-phenyl)-N5- [(3S)-3-piperidyl...)
Affinity DataKi:  0.341nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEphrin type-A receptor 2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808598BDBM808598(7-(2-fluoro-6-methyl-phenyl)-N5- [(3S)-3-piperidyl...)
Affinity DataKi:  24.6nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808598BDBM808598(7-(2-fluoro-6-methyl-phenyl)-N5- [(3S)-3-piperidyl...)
Affinity DataKi:  163nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent