BDBM808700 6-(2-chloro-6-methyl-phenyl)-N8-(1- ethyl-4-piperidyl)quinazoline-2,8- diamine::US12637428, Example E128

SMILES CCN1CCC(Nc2cc(-c3c(C)cccc3Cl)cc3cnc(N)nc23)CC1

InChI Key InChIKey=SDTFXPPOQAHDER-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 808700   

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808700BDBM808700(6-(2-chloro-6-methyl-phenyl)-N8-(1- ethyl-4-piperi...)
Affinity DataKi:  0.184nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808700BDBM808700(6-(2-chloro-6-methyl-phenyl)-N8-(1- ethyl-4-piperi...)
Affinity DataKi:  0.409nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808700BDBM808700(6-(2-chloro-6-methyl-phenyl)-N8-(1- ethyl-4-piperi...)
Affinity DataKi:  1.46nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEphrin type-A receptor 2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808700BDBM808700(6-(2-chloro-6-methyl-phenyl)-N8-(1- ethyl-4-piperi...)
Affinity DataKi:  20nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808700BDBM808700(6-(2-chloro-6-methyl-phenyl)-N8-(1- ethyl-4-piperi...)
Affinity DataKi:  26.4nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808700BDBM808700(6-(2-chloro-6-methyl-phenyl)-N8-(1- ethyl-4-piperi...)
Affinity DataKi:  27.4nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent