BDBM81393 MPI-0479883

SMILES Cn1c(CN2CCN(CCN)CC2)nc2cc(Cl)c(CN(CC#C)c3ccc(cc3)C(=O)NCc3cccnc3)cc2c1=O

InChI Key InChIKey=IXSHUAWZJLAPHA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 81393   

TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandPNGBDBM81393(MPI-0479883)
Affinity DataIC50: 0.170nMAssay Description:In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Kyowa Hakko Kogyo

LigandPNGBDBM81393(MPI-0479883)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of N-terminal 6His-tagged human NAMPT expressed in Escherichia coli BL21 (DE3) measured for 1 hr by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed