BDBM8156 N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-methoxypyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine::pyrazolo[1,5-b]pyridazine deriv. 47

SMILES COc1cc(Nc2nccc(n2)-c2cnn3nc(OC)ccc23)cc(c1)C(F)(F)F

InChI Key InChIKey=GJYVLTPTDBQQCY-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 8156   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50:  794nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50:  199nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50: >2.00E+4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))TBA
LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human CLK4More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA
LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human CLK1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))TBA
LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))TBA
LigandPNGBDBM8156(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{6-metho...)
Affinity DataIC50:  363nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
In DepthDetails PubMed