BDBM8270 2-chloro-5-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}benzoic acid::4-arylmaleimide deriv. 6aa::D3RKN_35

SMILES COc1cccc(c1)C1=C(Nc2ccc(Cl)c(c2)C(O)=O)C(=O)NC1=O

InChI Key InChIKey=CKNBSSMNQGLXEA-UHFFFAOYSA-N

Data  2 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 8270   

TargetGlycogen synthase kinase-3 alpha(Human)
Smithkline Beecham Pharmaceuticals

LigandPNGBDBM8270(2-chloro-5-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dih...)
Affinity DataIC50:  85nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlycogen synthase kinase-3 beta(Human)
University of Jordan

Curated by ChEMBL
LigandPNGBDBM8270(2-chloro-5-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dih...)
Affinity DataIC50:  85nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Nek2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM8270(2-chloro-5-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dih...)
Affinity DataKd:  460nMAssay Description:Inhibition of NEK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetTyrosine-protein kinase JAK2(Human)
D3R/Abbott

LigandPNGBDBM8270(2-chloro-5-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dih...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2022More data for this Ligand-Target Pair
In DepthDetails D3R


LigandPNGBDBM8270(2-chloro-5-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dih...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2023More data for this Ligand-Target Pair
In DepthDetails D3R


LigandPNGBDBM8270(2-chloro-5-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dih...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2021More data for this Ligand-Target Pair
In DepthDetails D3R