BDBM83408 3-(3-oxo-3-(4-(3-(trifluoromethyl)benzyl)piperazin-1-yl)propyl)-8-(trifluoromethyl)-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 34

SMILES Cc1ccc(C)c(N2CCN(C(=O)CCn3cnc4c([nH]c5ccc(C)cc54)c3=O)CC2)c1

InChI Key InChIKey=NXFHXKHJZZLXFW-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 83408   

TargetThiamine pyrophosphokinase 1(Human)
Shanghai Raising Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 83408BDBM83408(3-(3-oxo-3-(4-(3-(trifluoromethyl)benzyl)piperazin...)
Affinity DataEC50:  1.37E+3nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent