BDBM8355 6-aryl-pyrazolo[3,4-b]pyridine analogue 19::N-{5-cyano-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl}cyclopropanecarboxamide

SMILES O=C(Nc1n[nH]c2nc(-c3ccccc3)c(cc12)C#N)C1CC1

InChI Key InChIKey=PZKKJJYMVWVYOZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 8355   

TargetGlycogen synthase kinase-3 beta(Human)
University of Jordan

Curated by ChEMBL
LigandPNGBDBM8355(N-{5-cyano-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl...)
Affinity DataIC50: 87nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8355(N-{5-cyano-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl...)
Affinity DataIC50: 87nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2006
Entry Details Article
PubMed