BDBM83775 N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,4-thiadiazol-2-yl)-4-(4- (tetrahydrofuran-3-carbonyl)piperazin-1-yl)- 9H-pyrimido[4,5-b]indole-7-sulfonamide::US20250388589, Example 34

SMILES N#CC1(NS(=O)(=O)c2ccc3c4c(N5CCN(C(=O)C6CCOC6)CC5)ncnc4n(-c4nnc(C(F)F)s4)c3c2)CC1

InChI Key InChIKey=DOUHYOAPYODSTI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 83775   

TargetPoly(ADP-ribose) glycohydrolase(Human)
Danatlas Pharmaceuticals Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 83775BDBM83775(N-(1-Cyanocyclopropyl)-9-(5- (difluoromethyl)-1,3,...)
Affinity DataIC50: 0.000100nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent