BDBM9019 CHEMBL45::Melatonin::N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide

SMILES CC(=O)NCCc1c[nH]c2c1cc(cc2)OC

InChI Key InChIKey=DRLFMBDRBRZALE-UHFFFAOYSA-N

Data  176 KI  33 IC50  1 Kd  23 EC50  1 ITC

PDB links: 9 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 233 hits for monomerid = 9019   

TargetMelatonin receptor type 1A/1B(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 0.0170nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2019
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.0220nMAssay Description:Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.0260nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.0690nMAssay Description:Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.0692nMAssay Description:Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.0700nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMelatonin receptor type 1C(African clawed frog)
University College London

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.0794nMAssay Description:Effect on pigment aggregation in Xenopus laevis melanophoresMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.0800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.0823nMAssay Description:Ability to inhibit 2-[125I]iodomelatonin specific binding to human melatonin receptor type 1A (MT1) expressed in CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.0823nMAssay Description:Binding affinity against human Melatonin receptor type 1A (MT1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.0910nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.0910nMAssay Description:Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2016
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.0915nMAssay Description:Binding affinity against ovine pars tuberalis melatonin receptor using 2-[125I]- melatonin radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetMelatonin receptor type 1A/1B(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKd:  0.0915nMAssay Description:Binding affinity to melatonin receptor measured on ovine pars tuberalis membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.0980nMAssay Description:Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 0.110nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 0.110nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.120nMAssay Description:Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.120nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.120nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2019
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.120nMAssay Description:Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.130nMAssay Description:Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.140nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.140nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [125L]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.140nMAssay Description:Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as rad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.141nMAssay Description:Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.150nMAssay Description:Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2016
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.150nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 0.157nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.166nMAssay Description:Binding Affinity (pKi) towards human Melatonin receptor type 1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.174nMAssay Description:Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataEC50:  0.174nMAssay Description:Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMelatonin receptor type 1C(Chicken)
Cnrs-Biocis

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.176nMAssay Description:Effect of compound on Melatonin receptor in chicken brain in the presence of MnCl2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.180nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.180nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.180nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.190nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMed
TargetMelatonin receptor type 1B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.195nMAssay Description:Binding affinity against human Melatonin receptor type 1B (MT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.200nMAssay Description:Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.200nMAssay Description:Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 0.200nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 0.200nMAssay Description:Binding affinity to human MT1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
Displayed 1 to 50 (of 233 total ) | Next | Last >>

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 9019   

CellQuinone Reductase 2 (QR2)(Human)
University of Illinois At Chicago

SyringePNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
ITC DataΔG°: -8.06kcal/mole −TΔS°: 2.38kcal/mole ΔH°: -10.4kcal/mole logk: 7.14E+5
pH: 7.5 T: 25.00°C